Conolidine’s analgesic results stem from its interaction with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors in the central anxious system, conolidine modulates alternate molecular targets. A Science Developments review found that conolidine interacts Together with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://keeganvbvso.dailyblogzz.com/38728810/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers